Assignment: Best Practice for Colorectal Cancer in Women Essay

Assignment: Best Practice for Colorectal Cancer in Women Essay

Assignment: Best Practice for Colorectal Cancer in Women Essay

Colorectal Cancer

Studies such as Mori et al. (2017) reveal that colorectal cancer is the second most frequently occurring cancer in women. The condition denotes a type of cancer whose genesis is traced to the rectum or the colon. Further, the condition begins as a polyp on the internal lining of the colon or rectum. However, while certain polyps can become cancerous after an extended period, not all graduate into that. According to Botteri et al. (2017), pre-cancerous polyps known as Adenomatous polyps (adenomas) are the ones that change into cancer over time. However, for the polyps to become cancerous, they must be larger than 1 cm, more than two, and have dysplasia after their elimination since the former is a pre-cancerous condition. The risk of colorectal cancer appears particularly heightened in post-menopausal women. The reason for the increased risk of colorectal cancer in such women relates to the decreased levels of feminine hormone such as estrogen during this age (Mori et al., 2017). Therefore, the assessment and management of the condition needs to occur via the adoption of current best practices

Current Best Practices for Colorectal Cancer

Haziman, Ravinderan, Thangavelu, and Thomas (2019) posit that hormone replacement therapy such as estrogen-induced signaling leads to the suppression of tumor cells in colorectal cancer. Indeed, the application of hormone replacement therapy has garnered

worldwide support as one of the best practices in the management of CRC. In this study and others such as Botteri et al. (2017) and Mori et al. (2019), the adoption of HRT in clinical practice has direct correlation with reduction of CRC in post-menopausal women. Moreover, estrogen regulates the KCNQ1/KCNE3 potassium channel for purposes of modulating the body’s secretion of chloride when a woman menstruates. The KCNQ1 additionally acts a tumor suppressor, which is critical in the management of CRC in post-menopausal women. The tumor-suppressing properties of estrogen are thus leveraged by practitioners during the HRT so as to manage CRC.

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Comparison of Best Practices in WHI Article and Research Article

            The WHI article postulates that colorectal cancer is best managed through dietary modification interventions. During the study trial, a low-fat diet was tested regarding its efficacy to reduce the incidences of colorectal cancer in post-menopausal women (“Women’s Health Initiatives,” n.d.). Indeed, the WHI research revealed an inverse correlation between dietary fiber and colorectal cancer. Thus, the results of the Dietary Modification Trial as supported by the WHI have been adopted as current best practices in the assessment and management of colorectal cancer.

The usage of dietary modification as suggested by the WHI is similar to the hormone replacement therapy supported by Haziman, Ravinderan, Thangavelu, and Thomas (2019) since both practices entail the prevention of the disease in women. Both interventions reduce the occurrence of polyps in the rectum of post-menopausal women hence reducing the risk for CRC since pre-cancerous cells become limited. However, while the former intervention targets the physiological process to manage the CRC, the latter study influences the endocrine system. In addition, the manner in which they impact the surrounding body systems exist. Also, the former intervention seems safe while the HRT has potential side-effects, which makes it difficult to support.

Impact of Differences on Women Health

            The fact that the HRT targets the endocrine system makes it a sensitive treatment or preventative modality. Indeed, the differences reveal that the application of the HRET will depend on individual risks and potential benefits. Even then, the differences imply that women’s health is going to suffer as they reduce the available methodologies to support the fight against CRC in the post-menopausal women.

Use of HRT in Clinical Practice

            The HRT as suggested in the Haziman, Ravinderan, Thangavelu, and Thomas (2019) article should not be used in clinical practice. One of the principal reasons for the position relates to the controversies surrounding the intervention. Multifarious studies assert that while evidence has been adduced to its effectiveness, they have not been conclusive enough to warrant its adoption. Further, Holm et al. (2019) asserts that several studies have concluded that while the HRT could be effective as a way of managing CRT, its side-effects and the imbalance that it causes to the endocrine system makes it a secondary consideration in therapy. Thus, the CRT should not be used in clinical settings.

Describe the disorder you selected from the Women’s Health Initiative study.
Explain the current best practices for assessing and managing this disorder as suggested in the research article you selected.
Compare the best practices presented in the WHI study to the current best practices presented in the article. Explain how the differences in best practices might impact women’s health.
Explain whether you think the current best practices in the article you selected should be used in clinical practice. Support your position with evidence-based research.

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Assignment: Best Practice for Colorectal Cancer in Women Essay

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